The Candida Expert

Antibiotic-induced gastric cancer is not something that you typically hear about, but get ready to as more and more cases are happening as a result of antibiotic use. Doctors in Korea are stating that H. pylori, the number one risk factor for gastric cancer, has developed increased resistance to antibiotics, setting the stage for a greater number of untreatable stomach cancers.

It’s already a well-established fact that antibiotics induce the development of fungal candida infections, which then lead to ulcers, gastritis, cancer, and a host of other diseases and conditions. The likelihood that someone could get cancer increases two-fold as both antibiotics, and the subsequent fungal infections that they create, are both linked to causing cancer. Add to this the fact that the bacterial infection H. pylori is the strongest risk factor for stomach cancers and the outlook doesn’t look to promising.

While antibiotics are the main choice for medical doctors when it comes to treat H. pylori, the use of antibiotics creates fungal candida and rebound H.pylori infections that are now antibiotic resistant. As Dr. Morgan Scott, a Professor at Texas A&M University puts it, “As you use more and more antibiotics, you will have fewer and fewer bacteria that are susceptible,” he said. “My use today will diminish in some way your use in the future; these are the economics of a finite resource. 

If we look at the the two main theories on the development of cancer, we have one side stating that it’s genetic (DNA) and the other side saying it’s mitochondrial. Regardless of which side you choose to support, you’ll find antibiotics as a cause of cancers on both sides. Antibiotics have been shown to damage the DNA, mitochondria, lipids, and proteins of the cells of our body.

Antibiotic resistance is considered to be one of the top three threats to human health on the planet. We can now add stomach cancer to the list of antibiotic-induced cancers and diseases. As Dr. Scott points out, “We always need to seek alternatives to antibiotics because of the documented potential for any antibiotic to select for resistance to almost any other antibiotic.”

For years, experts and authorities have been warning us that the antibiotic era is coming to and end. The end is now here. In spite of all this, doctor’s prescribing habits have not changed. Antibiotic usage has increased over 36% in the last 10 years, most of it unnecessary. Worldwide, over 2 million people will die as a result of antibiotic resistance, more than those killed by AIDS.

Antibiotic usage creates imbalances within the body that need to be corrected. Taking N-acetylcysteine can help to minimize and avoid some of the cellular damage created by antibiotics. Reversing the damage after having taken antibiotics can diminish or avoid long-term complications that may not show up for years.

Get started on a healthier life today with Dr. McCombs Candida Plan!

Dr. Jeffrey S. McCombs, DC, is founder of the McCombs Center for Health, the Candida Plan, the Candida Library, and author of Lifeforce and The Everything Candida Diet Book.

The results are in for the Finals of the World Cup of Antibiotics. The patients have lost! Having come into the game as the clear underdog in this event, it was hoped that somehow they would be able to make it through and come out ahead of the relentless physician prescribing practices, which are heavily funded by the pharmaceutical industry. In the end, it was not to be as the antibiotic era came to a close and the body count was too high for the patients to survive against their stronger and more well-organized opponents.

At one point, it appeared as though the patients were gaining momentum, as several world figures and organizations came out declaring their support for the underdogs. Dame Sally Davies, Chief Medical Officer for Englanddeclared that ‘There is evidence that some GPs are dishing out more than they need to for medical clinical disease. ‘We’ve clearly got it wrong, and I would argue that GPs do need more training. If we don’t take action, deaths will go up and up and modern medicine as we know it will be lost.’ Dr Keiji Fukuda, the World Health Organisation’s Assistant Director-General for Health Security, wrote: ‘A post-antibiotic era — in which common infections and minor injuries can kill — far from being an apocalyptic fantasy, is instead a very real possibility for the 21st century.’ “If we are not careful, we will soon be in a post-antibiotic era,” Dr. Tom Frieden, the CDC’s director, said in a media briefing. “And for some patients and for some microbes, we are already there.”

The results of the match come as no surprise to many, as predictions about this outcome extend all the way back to the 1940s by the developer of antibiotics himself, the legendary Sir Alexander Fleming. Sir Fleming warned about how antibiotics would create resistant strains that would render them useless for patients. In the 1990s, Sen. Bill Frist, MD, testified before Congress that “If left unchecked, antimicrobial resistance forebodes a global public health crisis that threatens to return mankind and the practice of medicine to the pre-antibiotic era.” In 1999, Dr. James Hughes, the Director of the National Center for Infectious Diseases, stated “We are facing a serious global problem of antimicrobial resistance, that affects virtually all the pathogens we have previously considered to be readily treatable.”

The violations were obvious to anyone watching the event unfold, as time and time again, the warnings went unheeded. The pharmaceutical industry eventually balked at the idea of producing new antibiotics, as the writing was on the wall. Ultimately, all antibiotics would become useless and in their place would be so much resistance that even Sir Fleming would be shocked.

In spite of all the popular support and dire warnings, it was not to be however, as even refereeing organizations such as the FDA, that were charged with aiding and protecting all consumers, sat on the sidelines and did nothing, a clear indication that the pharmaceutical industry was winning. In one very clear example, the FDA had the chance to regulate unchecked antibiotic use in animals, but didn’t make the call and decided to let the industry regulate itself.

In a demonstration of complete hubris and arrogance, the physician-led team blamed it all on the patients, stating, “Most people who come in are asking for antibiotics. I don’t prescribe them when not necessary.” Those on the sidelines were not swayed by such statements however, as the prescribing power is clearly in the hands of the physicians, not the patients. Statistics clearly showed that the 36% increase in antibiotic-prescribing over a 10-year period could not be blamed on the patients.

As time ran out for the underdogs, Dr. Arjun Srinivasan, associate director of the Center for Disease Control and Prevention,  proclaimed the games final score – “We’re here. We’re in the post-antibiotic era. There are patients for whom we have no therapy.”

Dr. Oz, where are you when we need you?


Dr. Jeffrey S. McCombs, DC, is founder of the McCombs Center for Health, the Candida Plan, the Candida Library, and author of Lifeforce and The Everything Candida Diet Book.

Candida infections are occurring more frequently as the use of antibiotics continues to rise, despite warnings about practices of over-prescribing. As antibiotic use continues to increase, so too will chronic fungal candida infections and a host of problems that goes with them. Candida treatments vary depending on who you ask, but here are the 4 main choices with their pros and cons.

1) Medications

Medications are probably the only choice you’ll be given when working with a medical doctor, due to insufficient training and understanding of safer alternative choices. Many anti-fungal medications can have dangerous side effects and create rebound infections due to the development of anti-fungal resistant strains. One of the more common and safer choices is nystatin. Unfortunately, it doesn’t work systemically in the body and can create rebound infections, as well.

2) Herbs

Herbs are a very common choice among holistic doctors and have a very long record of safety and effectiveness. While medications will almost always be the choice in life-threatening conditions, herbs are more likely to be the choice for people affected by candida. In nature, fungus breaks down dead plant matter, therefore all plants have an anti fungal pharmacy that prevents this from happening while they are still alive. As a result, the variety of plants and herbs available to treat fungal infections is enormous. In Nature, plants aren’t known to create anti-fungal resistant strains and only tend to inhibit fungus, instead of attempting to destroy it like medications do. Herbs can be a great aid in suppressing fungal candida infections, but are unlike to produce long-lasting results. When used in conjunction with medications, they can help to improve the results of the medications, although other risks remain.

Some of the main anti-fungal herbs include garlic, oregano, grapefruit seed extract, black walnut, Pau d’Arco, olive leaf extract, rosemary, cinnamon, thyme, cloves, fennel, and Tea Tree oil. Many are used in combination for the greatest effectiveness.

3) Probiotics

The word probiotic means “for life.” Probiotics are typically beneficial bacteria and yeasts that help to build and repair the normal flora of the intestinal tract and other tissues. These micro-organisms have been in use as long as fermented foods have been on the planet. As with herbs, probiotics have demonstrated a higher degree of safety than medications. Probiotics were formally recognized by Russian scientist, Elie Metchnikoff in 1907, and the identification of different probiotics and the exploration of their benefits have been continued ever since.

Probiotics are known to support whichever immune system response is dominate at the time they are used. Since fungal candida manipulates the body’s immune response towards one that favors its own growth, it’s best to correct fungal imbalances first before taking probiotics. Additionally, fungal candida inhibits the re-colonization of the Lactobacillus strains that make up the majority of probiotic formulas available today. Correct fungal candida in the intestinal tract first, then add the probiotics. Once the probiotics are in place they will help to prevent fungal candida from returning.

Look for multistrain probiotic formulas  in order to achieve a broader effect and contribute to the diversity of the bacteria present. The greater one’s bacterial diversity, the greater their health.

4) Fatty Acids

Fatty acids are the individual building blocks that make up the oils we are familiar with. Olive oil for instance, is composed of oleic, linoleum, palmitic, stearic, and linolenic fatty acids. With a long history of use, fatty acids provide the best of all worlds when it comes to candida treatments. Derived from plants, fatty acids provide many of the same benefits. Many fatty acids are as effective as medications without the side effects or other risks.

Three fatty acids – caprylic acid, undecenoic acid, and lauric acid – have been found to be very useful in the treatment of candida. Of these three, undecenoic acid is the reigning king of candida treatments. Undecenoic acid was found to be more effective than lauric acid and as much as six times more effective than caprylic acid. Distilled from the oil of castor beans, it can also be found as a component of human sweat along with other fatty acids. It’s long history of use dates back to the introduction of antibiotics and their role in creating the rise of fungal infections in humans. Early dosages were twenty times the amount currently being used to successfully treat candida along with diet, so there is no need for concern as with medications.

Some people will choose to combine treatments.  Timing will still be the issue with probiotics, and side effects will be the issue with medications. All the above choices will produce some good results, but fatty acids will be the best and safest choice by far. For a more detailed approach on how you can regain your health, visit Dr. McCombs Candida Plan.

Treating candida successfully requires some basic knowledge that most websites and practitioners never address. Unfortunately, many of the candida treatment sites found on the Internet focus more on sales and very little on education. With candida, education is very important as medical doctors aren’t receiving any training on candida in school, which leaves a large gap in knowledge that creates a lot of confusion for the average person as they attempt to find solutions for issues related to candida. Many marketers take advantage of this confusion to sell their products quickly to whomever they can emotionally manipulate with their sales pitches. With over 54,000 studies on candida since the introduction of antibiotics in the 1940s, you needn’t be lost when searching for the truth amongst all the marketing. Here are some essential guidelines that can assist you on the road to health.

Successful candida treatments will follow six important guidelines:

1) Reduce easy sugar sources and pro-inflammatory foods.

A diet high in sugars can help to drive fungal candida infections, as is evidenced by the high percentage of diabetics who have fungal candida infections. The high blood sugar levels of a diabetic ensures that candida always has a ready food source available, which promotes more growth. Many people take this information to the extreme however, and restrict all forms of sugars, from table sugars to fruits and complex carbohydrates. The unfortunate side effect of this is that restricting all sugars also robs our body’s cells of the important carbohydrates that they need to function. While too much sugar can weaken the immune system, so can too little. Restricting all carbohydrates also changes the composition of the bacterial flora and can predispose someone to greater levels of intestinal inflammation, leaky gut, and conditions. Even if you were able to restrict all foods that candida could thrive on, it might only serve to stimulate and increase the numbers of fungal candida present. Candida is an amazing organism and can exist on protein and fats, as well as carbohydrates. Those who promote reducing all sugars are demonstrating how much they don’t know about about candida. Candida drives a lot of inflammation in the body, which is why it is associated with over 100 different conditions. An anti-inflammatory diet helps to reduce the levels of inflammation that candida creates. Diets high in histamine can promote more inflammation in the body, and inflammation drives the growth of candida. Restricting foods high in histamine (oranges, vinegar, fermented foods, smoked meats, beans, etc.) during the initial phase of a candida diet can help to control inflammation levels until fungal candida is corrected. High levels of histamine can cause an increase in mucus levels in the body that can affect absorption of nutrients and elimination of toxins.

2) Correct the fungal form back to its normal yeast form.

The best way to create health is to create balance, or homeostasis. If medications are used to treat candida, they create further imbalances, anti-fungal resistant strains of candida, and rebound infections. Anytime we attempt to ‘kill’ a microbe with antibiotics or antifungals, we create resistant strains of those species. Eventually, we can no longer use the same antimcrobial and have to use newer ones, which only creates more resistant strains. This is why antibiotic-resistance is one of the top 3 threats to humans on the planet and kills more people than AIDS each year. Herbs on the other hand are designed by nature to inhibit candida, not destroy it. Nature always works to create balance, not destruction, as is evidenced by the action of herbs. Herbs can be beneficial to take on any candida plan, but alone consistently fail to resolve fungal candida issues. Fatty acids have proven to be the safest way to address fungal candida safely and effectively. Amidst all of the options available, undecenoic acid has been shown to be the best choice. It safely converts the problematic fungal form of candida back to its normal yeast form. Undecenoic acid has been used for candida since the 1940s. Next best would be caprylic acid, but there may be some issues with long-term use and kidney function.

3) Boost the appropriate immune response.

Candida has an ability to manipulate our immune system responses. It drives Th2 immune responses that create inflammation, allergies, and illness. The opposite immune response, a Th1 response, helps to control and prevent fungal candida infections, as well as viral, parasite, and many bacterial infections. When correcting fungal candida infections, it is important to boost the Th1 immune response at the same time. This helps to ensure that candida doesn’t revert back to its fungal form. Substances such as vitamin C, echinacea, red clover, and bioflavonoids help to boost the appropriate immune system response. A formula containing all of these together works best.

4) Detoxify the body through ongoing elimination.

Many toxins that store in our body will drive Th2 immune responses and can interfere with healthy cellular function. As a part of creating better balance and health, detoxification is an ongoing issue. There are over 140,000 chemicals being added to the environment every year. Many chemicals store inside our body and lead to imbalances that support the growth of fungal candida. These toxins can create blood sugar problems, immune system suppression, hormonal imbalances, and other issues that facilitate the growth and spread of candida. Detoxifying the body while addressing candida helps to minimize and ensure that the body achieves better balance and function. Sweating is a good way to detoxify the body and provides additional health benefits. In many cultures, sweating is a tradition that has been around centuries. Keeping the bowels moving helps with the detoxification process and keeps the organs, tissues, and cells operating optimally. Normal daily bowel movements should be 3-4 times a day. Many people only have one a day, which leads to re-absorption of toxins, increased levels of inflammation, and cellular stress. Herbal colon formulas and Trace Minerals Concentrace help to keep your health moving in the right direction.

5) Only introduce probiotics after correcting fungal candida back to its yeast form.

Beneficial probiotic bacteria are an important piece when it comes to correcting fungal candida imbalances. Probiotics are known to support whichever immune response is dominant. Taking them too soon can support the wrong immune response. It is important to correct fungal candida first and boost the appropriate immune response before starting to take probiotics. Fungal candida is also known for inhibiting the recolonization of Lactobacillus bacterial strains in the body. As long as fungal candida is present, Lactobacilli bacteria will be inhibited by candida. Most probiotic formulas contain mostly Lactobacillus bacteria, diminishing their effectiveness until candida is addressed first. Wait until the fungal candida condition is corrected before adding in probiotics.

6) Keep the blood sugar balanced.

As stated above, high blood sugar levels can facilitate rapid candida growth. Low blood sugar levels can also create imbalances that affect the immune system, hormones, adrenals, and nervous system. Keeping the blood sugar levels balanced can help to ensure a successful candida treatment outcome. I have found that following our Blood Sugar Protocol helps to balance blood sugar problems when followed for 4 months. Utilizing all of these essential components together is the best way to ensure success when treating candida. You’ll never just be treating candida, as you’ll need to address the body as a whole.

Each of these approaches and others are all covered in “The Everything Candida Diet Book.” Included in the book, you’ll find 150 candida recipes to help ensure a successful dietary approach.

Using this approach, we have seen many miracles, as a balanced and healthy body can achieve anything. With the science to back what we do, plus the quality of service that we provide along the way, we feel that everyone can bridge the gap of knowledge and confusion that exist with candida.

Get started on a healthier life today with Dr. McCombs Candida Plan!

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If we are to have any chance at adapting and staying healthy in the toxic world that we’ve inherited and continue to create, we need to use the one thing that can adapt faster and more efficiently than we can, the human microbiome.

Bacteria, yeast, fungi, and all other microbes have been in existence on this planet far longer than humans. They have evolved and developed amazing abilities to adapt to extreme conditions of ice and heat, toxic chemicals, radiation, and the amazing abilities of each other. Their ability to adapt and survive was illustrated in 2012, when Georgia Tech was able to revive 500-million-year-old bacterial DNA. Humans, on the other hand, are embarrassing slugs on the evolutionary scale. Our adaptation rate is so slow, if it weren’t for the microbes protecting us, neither of us would exist at this point.

The human microbiome consists of over 10,000 species of microbes (bacteria, yeasts, parasites, etc) with a total population of over 100 trillion in and on the body. Human cells are a meager 10 trillion cells in comparison. This microbiome encases us in a protective biological bubble that ensures the ongoing survival of the human species. This microbial bubble is responsible for helping to digest foods, synthesize vitamins and nutrients, regulate immune system function, transform chemicals and heavy metals, protect us from radiation, influence brain function and growth, sustain pregnancies, and so forth. Our microbial friends are more nursemaid and teacher than anything else. These microbes have also been shown to influence the makeup and function of our DNA, leading some researchers to state that, “Perhaps the genes supplied by our microbes are part of what make us human.”

We are so interconnected with them that their health equals our health. The greater the degree of microbial diversity, the greater our state of health. Destroying that diversity through antibiotic use in humans and unchecked usage in animals has a devastating impact on health. Each antibiotic pill reduces diversity and increases the numbers of antibiotic-resistant bacteria. Antibiotic resistance is now considered to be one of the top three threats to human health on the planet. Obviously, every other life form on the planet isn’t represented in that statistic, but equally affected. Each new antibiotic that we roll out leads to newly-resistant organisms. Researcher Maria Gloria Dominguez-Bello states that humans have lost one-third of their microbial diversity. Altering and eliminating that bubble leaves us much more susceptible to the hostile environment that we’ve been busy creating on this planet.

What we currently know about the toxins in the environment is still in its infancy. Consider Polycyclic Aromatic Hydrocarbons (PAH). We already knew that they caused liver and kidney damage; cataracts; immunosuppression; asthma; lung, breast, skin, colon, and bladder cancers, but then we fond out that when they interact with nitrogen, as they commonly do in the environment, the effects are over 400 times worse. What’s 400 times worse than cancer?

There are over 140,000 registered chemicals entering the environment every year, and less than 1,000 have been tested for their effect on humans. The total number of chemicals registered through the Chemical Abstract Agency surpassed 50 million in 2009. Babies are being born with hundreds if not thousands of chemicals in their body. As researchers Stephen Rauch and Bruce Lanphear pointed out, “Pound for pound, they eat and breathe more environmental contaminants than adults.”

There are over 4,000 chemicals used in processed foods and over 2,000 in tap water. Up to 60-70 percent of the waterways are contaminated with toxins. No one escapes the toxic burden that goes with living on this planet. You can eat organic and drink filtered water all day long, and you’ll still be affected as long as you’re breathing.

Radiation is a part of the daily background of life, as well. Even as we face the effects of Fukushima, we are still experiencing radiation residues from atomic bomb testing in the 1940s, Three Mile Island in 1979, and Chernobyl in 1986. The long tail effect of the radiation disasters will be with us for decades to come.

The complexity of addressing the numerous exposures and effects multiplied by the number of days we spend on this planet is enormous. It is beyond man’s capacity. Obesity, diabetes, and practically every other known disease is on the rise. We are living longer, but not healthier.

We need the help of a superhero. We need something that can respond instantly to the daily onslaught. We need the microbiome.

Supporting the one thing that constantly supports us is the answer. Through a whole foods diet and managing our exposures, we might just have a chance.

Dr. Jeffrey S. McCombs, DC, is founder of the McCombs Center for Health, the Candida Plan, the Candida Library, and author of Lifeforce and The Everything Candida Diet Book.


There is a chasm of knowledge that doctors face every day as patients with complex issues, and sometimes not-so-complex issues, show up in a doctor’s office with an illness that defies everything the doctor knows. At this point, the doctor can delve into the abyss of the unknown, ready to discover new frontiers, or punt and tell the patients that it’s all in their head, implying a psychological/emotional imbalance as opposed to a physical one.

Psychological issues can have a big impact on the body’s physiology and function, and the connection is well-studied and researched, but doctors are often too willing to assume that the problem must be “mental” when faced with complex issues that originate in the physical form.

It’s uncomfortable for a doctor to face his professional mortality when all of his training has taught him that he learned all there is to know, but it can be even more devastating for a patient to be told that it’s all in their head when they know that it isn’t. Leaving a doctor’s office with a scarlet “M” for mental written on their charts only adds to the problem.

As more and more people fall outside of the easy diagnostic pictures of the past, doctors must learn to embrace the unknown and find real answers to real problems.

The human body is very complex, and much about it is still unknown. Medical training prepares a doctor to address what is known, which leaves a large group of patients out in the cold. As Frank Lipman found out when he was faced with treating everyday patients, “I was shocked that my training was not very helpful for at least three quarters of them.”

More and more doctors are beginning to question the status quo of medicine and seeking answers in alternative medical practices that their patients are flocking to.

As doctors leave behind the centuries old medical model, they are discovering the answers they were seeking in diet, nutrition, acupuncture, homeopathy, and other holistic modalities.

At the same time, they are learning to question the old paradigm that placed medical dogma ahead of the patient. They begin to question and challenge the role of medications in patient care, and in doing so, open doors that were previously closed to them.

The view of antibiotics as a panacea for every illness is replaced with the awareness of the vital importance of the bacterial flora of the body in health. The downside of antibiotic use is revealed, and doctors discover that antibiotics can play a role in creating disease in the body, as well as preventing it.

A five- to seven-day course of antibiotics can destroy the entire bacterial flora within days and cause a excessive release of bacterial toxins that then induces a permanent, or “primed” state of chronic brain inflammation. With that chronic state of inflammation, a patient can experience headaches, depressionanxiety, and nervousness. If left untreated long enough, it could eventually play a role in creating Alzheimer’sParkinson’schronic fatigue syndromeseizures and even obesity.

In the end, it might really be in the patient’s head, but for reasons a closed mind would never have seen. The once elusive cause reveals itself to the doctor who cares enough to search beyond the limits of his knowledge base.

Arjun Srinivasan of the CDC stated it best when he said, “Medicine is a study in humility, we learn every day that something we thought was true is not correct.”

Dr. Jeffrey S. McCombs, DC, is founder of the McCombs Center for Health, the Candida Plan, the Candida Library, and author of Lifeforce and The Everything Candida Diet Book.


Candida Questions

Here are three common questions that we get about Candida.


1) How Do I Know I Have Candida?

Dr. McCombs analysis of the research, dating back to 1949, shows that if you’ve ever done antibiotics, you’ll have systemic fungal candida. Most people however, won’t have any symptoms of fungal candida infections. Studies that have been done, show that candida albicans can persist undetected in the majority of individuals. For those of you have symptoms already, there’s really no short list of symptoms that would apply as fungal candida can affect every organ, tissue, and cell in the body, depending on several factors.

Commensal organisms, such as Candida albicans, are able to persistently colonize the host without causing symptoms.”
Interactions of the fungal pathogen Candida albicans with the host
Steffen Rupp
Future microbiology. 01/05/2007; 2:141-51.

“The frequencies of the carriage of yeast pathogens and of serum precipitins to a variety of candida antigens among 254 patients generally tended to increase with the length of the patient’s stay in hospital. This trend was observed even though none of the patients investigated showed signs or symptoms of superficial or systemic candidosis.”
Distribution of pathogenic yeasts and humoral antibodies to candida among hospital inpatients.
J Clin Pathol 1980;33:750-756 doi:10.1136/jcp.33.8.750

“…based on the 15 to 25% rate of asymptomatic colonization in healthy adults or adolescents and especially the high asymptomatic vaginal fungal burden in adolescents.
An Intravaginal Live Candida Challenge in Humans Leads to New Hypotheses for the Immunopathogenesis of Vulvovaginal Candidiasis
Infection and Immunity, May 2004, p. 2939-2946, Vol. 72, No. 5


2) What Causes Candida?

There’s only one thing that commonly creates fungal candida and that’s antibiotics. Antibiotics eliminate the bacterial flora and suppress immune system function. These two effects alter the pH, eliminate competitive inhibition and nutrient competition, stimulate the conversion of candida through release of signaling molecules from bacteria, and increase inflammation. With the exception of chemotherapy, nothing else creates the perfect situation for fungal candida growth.

Antibiotic treatment has also been shown to increase the rate of C. albicans isolation in stool (15; M. Barza, M. Giuliano, and S. Gorbach, Program Abstr. 25th Intersci.” Factors identified that facilitate this dissemination include suppression of the intestinal bacterial flora…”
Factors Affecting Colonization and Dissemination of Candida albicans from the Gastrointestinal Tract of Mice
INFECTION AND IMMUNITY, JUlY 1987, p. 1558-1563

Candida albicans infections often occur during or shortly after antibacterial treatment.”
Influence of fluoroquinolones on phagocytosis and killing of Candida albicans by human polymorphonuclear neutrophils
Thomas Grúger; Caroline Mörler; Norbert Schnitzler; Kerstin Brandenburg; Sabine Nidermajer; Regine Horré; Josef Zúndorf*%7Calbicans

Risk factors for candidaemia include breakdown of mucosal barriers due to cytotoxic chemotherapy and surgical procedures, neutropenia, changes in the gut flora due to antibiotics, and invasive interventions that breach the skin, such as intravenous lines and drains (Wey et al, 1989).”
The immune response to fungal infections
Shmuel Shoham1 and Stuart M. Levitz
1Section of Infectious Diseases, Washington Hospital Center, Washington, DC, and 2Department of Medicine, Boston Medical Center and
Boston University School of Medicine, Boston, MA, USA
British Journal of Haematology, 129, 569–582

“The composition of the microbiota is significantly affected by the use of antibiotics, which are often used extensively,…”
Host immune response to antibiotic perturbation of the microbiota
M Wlodarska and B B Finlay

“Mice were pretreated with antibacterial agents to alter their resident microflora, and then orally inoculated with C. glabrata and/or C. albicans. Elimination of detectable cecal bacteria facilitated colonization with both Candida species.”
Comparative abilities of Candida glabrata and Candida albicans to colonize and translocate from the intestinal tract of antibiotic-treated mice
Michelle J. Henry-Stanley; Robb M. Garni; Mary Alice Johnson; Catherine M. Bendel; Carol L. Wells*|albicans*

“…antibiotic therapy has been reported to precede disseminated candidiasis in children.”
Interaction of Candida albicans with Human Leukocytes and Serum

Oral antibiotic therapy in humans often leads to colonization and over-growth of the GI tract by C. albicans
Inhibition of Candida albicans Translocation from the Gastrointestinal Tract of Mice by Oral Administration of Saccharomyces boulardii
R. Berg, P. Bernasconi, D. Fowler, and M. Gautreaux
Dept of Microbiology and Immunology, Lousiana State University Medical Center, Shreveport and BIOCODEX, Montrouge, France
The Journal of Infectious Diseases, Vol. 168, No. 5 (Nov., 1993), pp. 1314-1318

Antibiotic treatment decreased the total population levels of the indigenous bacterial flora, and predisposed mice to gastrointestinal overgrowth and subsequent dissemination by Candida albicans, C. parapsilosis, C. pseudotropicalis, C. tropicalis, and Torulopsis glabrata.”
Dissemination of yeasts after gastrointestinal inoculation in antibiotic-treated mice
1983, Vol. 21, No. 1 , Pages 27-33

Antibiotic treatment decreased the total population levels of the indigenous bacterial flora and predisposed hamsters to gastrointestinal overgrowth and subsequent systemic dissemination by C. albicans in 86% of the animals.”
Ecology of Candida albicans Gut Colonization: Inhibition of Candida Adhesion, Colonization, and Dissemination from the Gastrointestinal Tract by Bacterial Antagonism
INFECTION AND IMMUNITY, Sept. 1985, p. 654-663


3) How Long Does It Take For Candida To Spread In The Body?

It happens much faster than most people would imagine. In a matter of hours after taking antibiotics, fungal candida can escape the intestinal tract and make its way through the body.

“Oral-intragastric inoculation of 5-6-day-old mice with yeast of a virulent strain of Candida albicans (CA30) resulted in systemic spread within 30 min after challenge. Histological examinations of the gastrointestinal (GI) tract have shown that the highest frequency of invasion of the mucosa by yeast cells occurred in the region of the jejunum 1-3 h after inoculation. Results of ultrastructural examinations of sites where the fungus invaded the bowel wall suggested that C. albicans yeast cells are capable of progressive extracellular digestion of the intestinal mucus barrier and microvillus layer, followed by intracellular invasion of columnar epithelial cells.”
Morphological aspects of gastrointestinal tract invasion by Candida albicans in the infant mouse.
J Med Vet Mycol. 1988 Jun;26(3):173-85.

“The pseudomycelium was found to invade animal epithelia at an average rate of 2 microns per hour, penetrating the entire epithelial thickness during 24-48 h. These data have been extrapolated to clinical pathology. On the basis of experimental data and by measuring the epithelial thickness in some human mucous membranes, the presumable periods of total epithelial penetration were calculated which may lead to vascular invasion and create the danger of dissemination. For different human mucous membranes these periods ranged from 22 to 59 h.”
Velocity of Candida albicans invasion into host tissues.
Mycoses ; 34:293-6.

“Critical times in the development of infections in optimally challenged BALB/c mice were at 5-10 h (bloodstream fully cleared of fungi), 24 h (start of exponential fungal growth in kidneys) and 48 h (50% of blood cultures become positive.”
Temporal events in the intravenous challenge model for experimental Candida albicans infections in female mice.
Mycoses. 2005 May;48(3):151-61.


Get started today with Dr. McCombs Candida Plan.

This was a podcast that I did a few weeks back. The sound quality on my end is not so great, but the information is still valuable –


Are you one of the growing number of “HIV positives” who reject the “antiretroviral” drugs, T-cells and “viral load” counting, and the general fear around “AIDS” – but still perceive that you have a weak immune system? It may not be “all in your head.” Digestive problems, constipation, hormone imbalances, headaches, “brain fog,” allergies, hypoglycemia, fatigue, skin problems such as psoriasis and eczema — links to cancers, Parkinson’s, diabetes and obesity – and even, possibly, heart disease –may be signs of inflammation caused by a dangerous fungal growth. Dr. Jeffrey McCombs reveals Candida albicans as the common factor in more than 100 diseases.

Mainstream sources describe Candida as caused by HIV, but they could be raising the question of what AIDS is in the first place. It looks a lot like Candida to us!


Southern California chiropractor Dr. McCombs is the author of Life Force: A Dynamic Plan for Health, Vitality and Weight Loss and, just released this summer of 2014,The Everything Candida Diet Book. He has maintained The Candida Library, an online resource for practitioners and patients, since 2011.

In his conversation with “How Positive Are You” co-hosts David Crowe and Elizabeth Ely, several surprising facts emerged:

  • Government-sponsored online medical database PubMed reveals almost no studies on the effects of Candida albicans on the human body before 1945 – not so coincidentally, about the time that antibiotics were first introduced.
  • These days, up to five research studies on Candida are initiated every day, yet this condition is not taught in medical schools, and your doctor may not even know how to look for it.
  • Most tests for Candida fail to distinguish between the yeast and fungal forms of this organism, and taking probiotics without addressing this difference can make the fungal form even more damaging.
  • The dangers of antibiotics go far beyond killing beneficial bacteria in the gut and include damaging the mitochondria inside cells, growing bacterial resistance, establishing a Th1/Th2 imbalance within the immune system and causing permanent brain damage. (HPAY plans to talk more about the Th1/Th2 subsets of T-cells in the future, so stay tuned. . . .)
  • Astronauts get Candida-related symptoms while working in space.

As we discussed in a previous episode of HPAY, antibiotics and their devastating cousins the “HIV antiretrovirals” take us into bacterial resistance and dependence on ever more powerful drugs. Our warlike, carpet-bombing medical system tries to eradicate all threats – with plenty of collateral damage. As an alternative, the key to restoring balance, Dr. McCombs says, is converting inflammatory, “tumbleweed”-shaped fungal forms back to beneficial yeast forms.

Dr. McCombs takes a limited number of patients and can be reached by phone or Web through information on his “Contact Us” page.

Last week, the mighty Dr. Oz took his celebrity show on the road to Washington, DC. Instead of a warm reception, the great and powerful Oz found himself in the hot seat being chided by a Senator from the back woods of Missouri over the use of his show for promoting weight loss cures.

This inquisitional hearing was held under the pretenses of a Congressional committee on Consumer Protection looking into the steps being taken by the supplement industry to safeguard the health and safety of U.S. citizens. Industry leaders, such as Daniel Fabricant, CEO of the Natural Products Association and Steve Mister, CEO of the Council for Responsible Nutrition, were summoned to be present along with the Mary Koelbel Engle, head of the Federal Trade Commission’s Division of Advertising Practices, Robert Haralson, Executive Director of, and C. Lee Peeler, CEO of Advertising Self-regulatory Council.

After the obligatory introductions and position statements by each of the honored guests, the true purpose of the meeting was revealed as chairwoman, Sen. McCaskill turned on Dr. Oz like a Jerry Springer Show guest and began her attack. Everyone else from the supplement industry at this point could have gone home, as their presence was only a brief warm-up to the main show now playing.

Calling upon her years of experience as a trial lawyer, McCaskill quickly cornered Dr. Oz with videos and transcripts from his show that demonstrated his penchant for stretching the truth a bit. Much like a child being scolded for the use of profanity, Dr. Oz found himself being scolded for his use of  “flowery” language on his show. Eager to show that she also was capable of competing with Oz in the flowery language categories, McCaskill offered up phrases like “monolithic” and “false hope.” Sen. McCaskill came back again and again, and the Oz offered up a noble defense of his tactics. All of this was too much like life imitating art. Recalling this scene from the Wizard of Oz with Dorothy and the Wizard gives a good idea of the entire exchange -

Dorothy: (scolding) Oh, you’re a very bad man!
The Wizard (sadly): Oh, no, my dear, I…I’m a very good man – I’m just a very bad Wizard.

No doubt that this hearing was the highest rated Congressional meeting in the last 50 years, and perhaps all time. Fortunately for those watching, it was commercial free, so there were no pharmaceutical ads running every 5 minutes, although their presence was palpable given the donations that Sen. McCaskill has received from the pharmaceutical industry.

In contrast to Sen. McCaskill, all of the other inquisitors were almost apologetic in their questions of the mighty Oz, possibly fearful of the backlash against themselves by the millions of Oz fans throughout the country come re-election time. The only other point of interest in the entire hearing was when Sen. Klobuchar asked, “Do you think there should be more FDA regulation…?”, to which Mary Koelbel Engle of the FTC graciously pointed out that much of what is needed is already being done. In other words, no thank you.

I’m one of the few people who have never seen the Dr. Oz show, but I was interested in observing this meeting as it was supposedly going to have implications for the vitamin and supplement industry, products that I use in assisting people to get well. Most of my time is spent in my office treating real problems with real solutions. An MD whose gone Hollywood and promotes miracle pills for weight loss holds little interest for me. If anything, such promotions only serve to increase his show’s ratings, while contributing to the ongoing misconceptions and lack of personal responsibility that surround most health issues. Why change your lifestyle when you can just swallow a pill. It’s the typical solution for most Americans and one of the main reasons that obesity and diabetes, as well as almost every other disease, are on the rise.

All-in-all, everyone was very civil, and the Oz effect was very present. Dr. Oz has a TV show and exaggeration is the norm. Congress and politics, however, are no different. Flowery words and politics go hand-in-hand. Consider these words spoken by Sen. McCaskill in an acceptance speech, “…this was an extraordinary campaign, the results are astounding. Now, I want all of you to own it. You deserve it.” Sounds like words straight out of the land of Oz.

When all was said and done, Sen. McCaskill clicked her ruby slippers together three times and mumbled something about Hillary Clinton being a pinata, and not wanting to let her daughter near Bill. Life goes on.

Candida and Diabetes are two common conditions that occur as a result of past antibiotic use. Each condition supports the existence of the other, but fungal candida alone can create diabetes through direct and indirect means.

Diabetes is a condition in which regulation of the level of sugar (Glucose) in the blood has been altered. The hormone insulin is responsible for ensuring that blood sugar levels don’t get too high. Insulin, a protein-based hormone produced by the pancreas, moves sugar from the blood into the cells and tissues. There are two main types of diabetes, Type I and Type II. Type I is primarily diagnosed in children and is considered to be an autoimmune condition. Type II is primarily diagnosed in adults due to lifestyle and other factors. Type II is the most common form. There are over 20 million adults with diabetes, and 40 million with pre-diabetes.

Both the incidence and prevalence of diabetes and candida have risen steadily since the introduction of antibiotics in the 1940s. Diabetes has now become the leading cause of death among various ethnic groups and is the 6th leading cause of deaths in the United States. Worldwide, according to the World Health Organization (WHO), over 347 million people have diabetes and approximately 3.5 million die as a result of it.

In 1940, there were no recorded studies on candida. Now there are over 53,000 studies, with 2466 recorded in 2013 alone. The incidence of both systemic fungal candida and diabetes have risen sharply in recent years.

Candida affects the body through various means. One of its primary tools for destroying tissues and acquiring nutrients in the body is through enzymes it produces called Secreted Aspartyl Proteases (SAPs). SAPs are considered to be candida’s main mechanism of virulence or pathogenicity – how it spreads in the body and causes damage. Researchers at the University of California in San Diego found that this protease class of enzymes can cause pre-diabetes, immune system suppression, and high blood pressure. Pre-diabetes conditions include insulin-resistance and hypoglycemia. Insulin attaches to receptors on cells that then activate the absorption of sugar from the blood. These protease enzymes will chop off the receptors on cells causing blood sugar levels to increase.

Candida can also lead to diabetes by driving the production of Th-17 immune cells that are also known to cause diabetes.

People with diabetes have been found to a higher incidence of candida infections affecting various tissues and organs. Excess sugars are an excellent source of fuel that can rapidly increase the growth of candida.

Candida also plays a role in shaping of the intestinal flora, which has been found to regulate blood sugar levels through its effects on organs such as the pancreas and liver.

The ability of the body to eliminate candida is in part based on the effectiveness of white blood cells. High or low levels of sugar in the blood reduces the effectiveness of these white blood cells., leaving candida to create ongoing disturbances and imbalances.

While many of these effects are in regard to Type II diabetes, candida has been shown to be able to create autoimmune conditions such as Type I diabetes.

The connection between antibiotics, candida, and diabetes is without question. Effective management of the various factors involved can bring resolution to conditions such as diabetes and many others.

Start living a healthier life today with Dr. McCombs Candida Plan.


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